How Does It Work?
In Parkinson disease nerve cells are dying because certain neuro-toxic substances are accumulating in these nerve cells. Since these cells play an important role in the coordination and execution of movements, people develop symptoms such as slowing of movements, tremor (shaking of hands) and muscle stiffness.
The shark compound that can be found in the liver of dogfish sharks is called squalamine. The new study showed that squalamine could be able to protect these nerve cells from the neuro-toxins called α-synuclein.
“To our surprise, we found evidence that squalamine not only slows down the formation of the toxins associated with Parkinson’s Disease, but also makes them less toxic altogether,” said Professor Christopher Dobson, of St John’s College at Cambridge University.
The study was published in Proceedings Of The National Academy Of Sciences.
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In Parkinson’s disease, certain nerve cells (neurons) in the brain gradually break down or die. These certain nerve cells are responsible for the design, the development and the realization of movements. The loss of neurons results in a decreased dopamine level in the brain. Dopamine is a chemical messenger between nerve cells.