• Depression and Parkinson’s | The big link

    Depression may either be a very early symptom of PD, or a causal risk factor. New research published in Neurology shows direct association between depression and subsequent Parkinson’s disease.


    • On average, Parkinson’s disease was diagnosed 4.5 years after the beginning of the study

    • After 15-25 years, participants with depression were almost 50% more likely to develop Parkinson’s disease

    • Severity of depression increases Parkinson’s risk even more

    • No sibling link found for depression and Parkinson’s disease, not caused by the same genetic or early environmental factors

    • Nationwide study cohort included 562,631 participants. 140,688 cases of depression, 421,718 not been diagnosed with depression, matched 1:3 using a nested case-control design to evaluate temporal aspects of study parameters

    • Potential familial coaggregation of the 2 diagnoses was investigated in a subcohort of 540,811 sibling pairs.

    • Follow-up up to 26 years.


    • All the facts about Parkinson’s Disease

    • Link to study


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