{"id":19348,"date":"2017-09-17T03:39:41","date_gmt":"2017-09-17T03:39:41","guid":{"rendered":"http:\/\/www.gncdubai.com\/?p=19348\/"},"modified":"2023-03-29T12:45:05","modified_gmt":"2023-03-29T08:45:05","slug":"longtime-antidepressant-slow-parkinsons","status":"publish","type":"post","link":"https:\/\/www.gncdubai.com\/ar\/longtime-antidepressant-slow-parkinsons\/","title":{"rendered":"Longtime antidepressant could slow Parkinson\u2019s"},"content":{"rendered":"

Michigan State University scientists now have early proof that an antidepressant drug that\u2019s been around for more than 50 years could slow the progression of Parkinson\u2019s.<\/em><\/p>\n

Source: Michigan State University<\/a>, Published: Sept. 5, 2017, Contact(s): Tim Collier , Sarina Gleason<\/p>\n

In a proof-of-concept study, published in the journal Neurobiology of Disease, the drug nortriptyline, which has been used to treat depression and nerve pain, stopped the growth of abnormal proteins that can build up in the brain and lead to the development of the disease.<\/p>\n

\u201cDepression is a very frequent condition associated with Parkinson\u2019s, so we became interested in whether an antidepressant could modify how the disease progresses,\u201d said Tim Collier, lead author of the federally funded study and a neuroscientist at MSU.<\/p>\n

Collier and collaborator Katrina Paumier, an assistant professor of molecular medicine, began looking at previous patient data to see if individuals who were on antidepressants experienced any delay in their need to go on a standard Parkinson\u2019s therapy called levodopa. This type of therapy increases levels of dopamine, a natural chemical in the body that sends signals to other nerve cells and can significantly decrease in cases of Parkinson\u2019s.<\/p>\n

The medication also treats many of the symptoms associated with the disease such as tremors and poor muscle control.<\/h2>\n

\u201cWe found that those on a certain class of antidepressant, called tricyclics, didn\u2019t need the levodopa therapy until much later compared to those who weren\u2019t on that type of antidepressant medication,\u201d Collier said.<\/p>\n

Collier then began testing rats with the tricyclic antidepressant nortriptyline and found that it indeed was able to decrease the amount of abnormal protein that can build up in the brain. This protein, known as alpha-synuclein, can cause the brain\u2019s nerve cells to die when in a clustered state and is a hallmark sign of the disease.<\/p>\n

To further back up his research, he enlisted the help of his colleague and co-author Lisa Lapidus, who in previous studies had already detected whether certain compounds could bind to alpha-synuclein and stop it from accumulating.<\/p>\n

\u201cProteins are constantly moving and changing shape,\u201d said Lapidus, a professor in the Department of Physics and Astronomy. \u201cBy using a test tube model, we found that by adding nortriptyline to the alpha-synuclein proteins, they began to move and change shape much faster, preventing the proteins from clumping together. The idea that this clustering effect is controlled by how fast or slow a protein reconfigures itself is typically not a standard way of thinking in research on proteins, but our work has been able to show these changes.\u201d<\/p>\n

Understanding how these proteins can clump together could point researchers in new directions and help them find other possible drugs that could potentially treat Parkinson\u2019s.<\/p>\n

\u201cWhat we\u2019ve essentially shown is that an already FDA-approved drug that\u2019s been studied over 50 years and is relatively well tolerated could be a much simpler approach to treating the disease itself, not just the symptoms,\u201d Collier said.<\/p>\n

Collier is already looking for funding for the next phase of his research and hopes to lead a human clinical trial using the drug in the future.<\/p>\n

The National Institutes of Health, as well as the Michael J. Fox and Saint Mary\u2019s Foundations, funded the study.<\/p>\n

Source: Michigan State University,<\/a> Published: Sept. 5, 2017, Contact(s): Tim Collier , Sarina Gleason<\/p>\n

 <\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Michigan State University scientists now have early proof that an antidepressant drug that\u2019s been around for more than 50 years could slow the progression of Parkinson\u2019s. Source: Michigan State University, Published: Sept. 5, 2017, Contact(s): Tim Collier , Sarina Gleason In a proof-of-concept study, published in the journal Neurobiology of Disease, the drug nortriptyline, which<\/p>\n","protected":false},"author":1,"featured_media":19349,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-19348","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"yoast_head":"\nLongtime antidepressant could slow Parkinson\u2019s<\/title>\n<meta name=\"description\" content=\"Michigan State University scientists now have early proof that an antidepressant drug that\u2019s been around for more than 50 years could slow the progression of Parkinson\u2019s.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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