{"id":18522,"date":"2016-12-25T07:08:21","date_gmt":"2016-12-25T07:08:21","guid":{"rendered":"http:\/\/www.gncdubai.com\/?p=18522"},"modified":"2016-12-25T07:08:21","modified_gmt":"2016-12-25T07:08:21","slug":"with-common-pain-killer-ibuprofen-against-alzheimers","status":"publish","type":"post","link":"https:\/\/www.gncdubai.com\/ar\/with-common-pain-killer-ibuprofen-against-alzheimers\/","title":{"rendered":"With Common Pain Killer (Ibuprofen) Against Alzheimer\u2019s"},"content":{"rendered":"<p><em>Researchers found out the Ibuprofen and other NSAR\u2019s might reduce the risk of developing Alzheimer\u2019s.<\/em><\/p>\n<p>Non-steroidal anti-inflammatory drugs (NSAR\u2019s) show certain effects in the brain. They inhibit enzymes involved in inflammatory processes and they reduce the over-expression of enzymes involved in cognitive impairment. Thus NSAR\u2019s are able to counteract certain pathological changes in Alzheimer\u2019s disease.<\/p>\n<p>These results are promising but further research is needed to see the effects on the human brain.<\/p>\n<h2>Study Summary<\/h2>\n<p>Identifying preventive targets for Alzheimer\u2019s disease is a central challenge of modern medicine. Non-steroidal anti-inflammatory drugs, which inhibit the cyclooxygenase enzymes COX-1 and COX-2, reduce the risk of developing Alzheimer\u2019s disease in normal ageing populations. This preventive effect coincides with an extended preclinical phase that spans years to decades before onset of cognitive decline. In the brain, COX-2 is induced in neurons in response to excitatory synaptic activity and in glial cells in response to inflammation. To identify mechanisms underlying prevention of cognitive decline by anti-inflammatory drugs, we first identified an early object memory deficit in APPSwe-PS1\u0394E9 mice that preceded previously identified spatial memory deficits in this model. We modelled prevention of this memory deficit with ibuprofen, and found that ibuprofen prevented memory impairment without producing any measurable changes in amyloid-\u03b2 accumulation or glial inflammation. Instead, ibuprofen modulated hippocampal gene expression in pathways involved in neuronal plasticity and increased levels of norepinephrine and dopamine. The gene most highly downregulated by ibuprofen was neuronal tryptophan 2,3-dioxygenase (Tdo2), which encodes an enzyme that metabolizes tryptophan to kynurenine. TDO2 expression was increased by neuronal COX-2 activity, and overexpression of hippocampal TDO2 produced behavioural deficits. Moreover, pharmacological TDO2 inhibition prevented behavioural deficits in APPSwe-PS1\u0394E9 mice. Taken together, these data demonstrate broad effects of cyclooxygenase inhibition on multiple neuronal pathways that counteract the neurotoxic effects of early accumulating amyloid-\u03b2 oligomers.<\/p>\n<p>Source: <a href=\"http:\/\/brain.oxfordjournals.org\/content\/early\/2016\/05\/11\/brain.aww117\" target=\"_blank\">Brain<\/a><\/p>\n<div id=\"kpm_content_wrapper\" class=\"notranslate\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Researchers found out the Ibuprofen and other NSAR\u2019s might reduce the risk of developing Alzheimer\u2019s. Non-steroidal anti-inflammatory drugs (NSAR\u2019s) show certain effects in the brain. They inhibit enzymes involved in inflammatory processes and they reduce the over-expression of enzymes involved in cognitive impairment. Thus NSAR\u2019s are able to counteract certain pathological changes in Alzheimer\u2019s disease.<\/p>\n","protected":false},"author":1,"featured_media":18523,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-18522","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.5 (Yoast SEO v28.5) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>With Common Pain Killer (Ibuprofen) Against Alzheimer\u2019s<\/title>\n<meta name=\"description\" content=\"Researchers found out the Ibuprofen and other NSAR\u2019s might reduce the risk of developing Alzheimer\u2019s. 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