{"id":17647,"date":"2016-06-12T03:55:57","date_gmt":"2016-06-12T03:55:57","guid":{"rendered":"http:\/\/www.gncdubai.com\/?p=17647"},"modified":"2016-06-12T03:55:57","modified_gmt":"2016-06-12T03:55:57","slug":"breakthrough-one-cause-multiple-sclerosis-found-accident","status":"publish","type":"post","link":"https:\/\/www.gncdubai.com\/ar\/breakthrough-one-cause-multiple-sclerosis-found-accident\/","title":{"rendered":"Breakthrough: One cause of multiple sclerosis found \u2013 by accident"},"content":{"rendered":"<p><em>So far the cause of multiple sclerosis was unknown. Now researchers at the University of Duisburg-Essen, Germany found a possible cause and a possible treatment.<\/em><\/p>\n<p>Accidentally the researchers found a connection between the blood coagulation system and the immune system. The coagulation factor XII (FXII) seems to play an important role in the development of auto-immune disease multiple sclerosis. This approach is completely new and was never investigated before.<\/p>\n<h2>Accidental discovery in the laboratory \u2013 Cause of MS found<\/h2>\n<p>The blood level of FXII is extremely high in patients with MS during a relapse. The researchers found that FXII activates the immune system \u2013 especially the production of Interleukin-17A &#8211; which causes the symptoms of the auto-immune disease MS. Moreover the researchers could show that mice without the FXII gen showed less symptoms.<\/p>\n<p>In a second step the researchers showed the effectiveness of a new treatment for multiple sclerosis. The protein Infestin-4 blocks FXII and thus reliefs MS symptoms, even if the disease was in a progressive state.<\/p>\n<p>The researchers concluded: \u201cOur study demonstrates that a member of the plasmatic coagulation cascade is a key mediator of autoimmunity. FXII inhibition may provide a strategy to combat MS and other immune-related disorders.\u201d<\/p>\n<p>However, Prof. Dr. Christoph Kleinschnitz, director of the institute, mentioned that it could take some time till the new treatment would be available.<\/p>\n<blockquote class=\"wp-embedded-content\" data-secret=\"iD0tI3uS2K\"><p><a href=\"https:\/\/www.gncdubai.com\/disease\/neurological-multiple-sclerosis\/\">MS Multiple Sclerosis<\/a><\/p><\/blockquote>\n<p><iframe loading=\"lazy\" class=\"wp-embedded-content\" sandbox=\"allow-scripts\" security=\"restricted\" style=\"position: absolute; visibility: hidden;\" title=\"&#8220;MS Multiple Sclerosis&#8221; &#8212; German Neuroscience Center Dubai\" src=\"https:\/\/www.gncdubai.com\/disease\/neurological-multiple-sclerosis\/embed\/#?secret=L5bE7b7Yoh#?secret=iD0tI3uS2K\" data-secret=\"iD0tI3uS2K\" width=\"500\" height=\"282\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\"><\/iframe><\/p>\n<p>References:<a href=\"https:\/\/www.uni-due.de\/de\/presse\/meldung.php?id=9404\" target=\"_blank\">University of Duisburg<\/a><\/p>\n<div style=\"width: 0; height: 0; visibility: hidden; opacity: 0; position: absolute;\"><object id=\"kpm_plugin\" type=\"application\/x-KPMPlugin\" width=\"300\" height=\"150\"><\/object><\/div>\n<div style=\"width: 0; height: 0; visibility: hidden; opacity: 0; position: absolute;\"><object id=\"kpm_plugin\" type=\"application\/x-KPMPlugin\"><\/object><\/div>\n","protected":false},"excerpt":{"rendered":"<p>So far the cause of multiple sclerosis was unknown. Now researchers at the University of Duisburg-Essen, Germany found a possible cause and a possible treatment. Accidentally the researchers found a connection between the blood coagulation system and the immune system. The coagulation factor XII (FXII) seems to play an important role in the development of<\/p>\n","protected":false},"author":1,"featured_media":17648,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-17647","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"_links":{"self":[{"href":"https:\/\/www.gncdubai.com\/ar\/wp-json\/wp\/v2\/posts\/17647","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.gncdubai.com\/ar\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.gncdubai.com\/ar\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.gncdubai.com\/ar\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.gncdubai.com\/ar\/wp-json\/wp\/v2\/comments?post=17647"}],"version-history":[{"count":0,"href":"https:\/\/www.gncdubai.com\/ar\/wp-json\/wp\/v2\/posts\/17647\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.gncdubai.com\/ar\/wp-json\/wp\/v2\/media\/17648"}],"wp:attachment":[{"href":"https:\/\/www.gncdubai.com\/ar\/wp-json\/wp\/v2\/media?parent=17647"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.gncdubai.com\/ar\/wp-json\/wp\/v2\/categories?post=17647"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.gncdubai.com\/ar\/wp-json\/wp\/v2\/tags?post=17647"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}