{"id":16549,"date":"2015-11-04T04:03:30","date_gmt":"2015-11-04T04:03:30","guid":{"rendered":"http:\/\/www.gncdubai.com\/?p=16549"},"modified":"2015-11-04T04:10:39","modified_gmt":"2015-11-04T04:10:39","slug":"new-hope-for-migraine-sufferers-new-drug-shows-promising-results","status":"publish","type":"post","link":"https:\/\/www.gncdubai.com\/ar\/new-hope-for-migraine-sufferers-new-drug-shows-promising-results\/","title":{"rendered":"New hope for migraine sufferers: New drug shows promising results"},"content":{"rendered":"<h2>Migraine is a common and severe disease that affects 15% of the general population.<\/h2>\n<p>\u201cMigraine, especially in patients with chronic migraine or high-frequency episodic migraine, causes substantial disability in nearly all aspects of life, including employment, household work, and social activities. The Global Burden of Disease Study ranks migraine as the eighth most common cause of years lived with disability.\u201d says Dr. Julio Pascual, University Hospital Marqu\u00e9s de Valdecilla, Spain<\/p>\n<p>Migraine is divided into three types: episodic migraine (&lt;15 headache-days per month), high-frequency episodic migraine (HFEM) (8-14 headache-days per month) and chronic migraine (\u226515 headache-days per month).<\/p>\n<h2>New migraine drug<\/h2>\n<p>The new drug is called TEV-48125. It is a monoclonal anti-CGRP antibody. That means it is a modified antibody against a certain structure in the human body called Calcitonin gene-related peptide (CGRP). CGRP is known to play an integral role in the pathophysiology of migraine.<\/p>\n<p>CGRP is responsible for the dilation of blood vessels in the brain, inflammation of nerves, and transmitting pain signals for the blood vessels in the brain to the nervous system.<\/p>\n<p>Therefore CGRP is a target for many new preventive migraine drugs.<\/p>\n<h2>New study<\/h2>\n<p>The study was published in <a href=\"http:\/\/www.thelancet.com\/journals\/laneur\/article\/PIIS1474-4422%2815%2900249-5\/fulltext\" target=\"_blank\">The Lancet<\/a>. It was a multicentre, randomised, double-blind, placebo-controlled, phase 2b study. The 297 participants reported headache information daily using an electronic diary. The study was funded by Teva Pharmaceuticals.<\/p>\n<h2>Results<\/h2>\n<p>\u201cTEV-48125, at doses of 225 mg and 675 mg given once every 28 days for 12 weeks, was safe, well tolerated, and effective as a preventive treatment of high-frequency episodic migraine&#8230;\u201d says the study&#8217;s author.<\/p>\n<h2>More info<\/h2>\n<p>here you can find more information about <a href=\"http:\/\/www.gncdubai.com\/disease\/neurological-migraine-headache\/\" target=\"_blank\">migraine<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Migraine is a common and severe disease that affects 15% of the general population. \u201cMigraine, especially in patients with chronic migraine or high-frequency episodic migraine, causes substantial disability in nearly all aspects of life, including employment, household work, and social activities. The Global Burden of Disease Study ranks migraine as the eighth most common cause<\/p>\n","protected":false},"author":1,"featured_media":16239,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-16549","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.5 (Yoast SEO v28.5) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>New hope for migraine sufferers: New drug shows promising results<\/title>\n<meta name=\"description\" content=\"New hope for migraine sufferers. A new drug showed promising results in terms of safety, tolerability, and efficacy. 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